Rylan Schaeffer

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29 March 2021

Extinction-Reconsolidation Boundaries - Key to Persistent Attenuation of Fear Memories

by Monfils, ..., LeDoux (Science 2009)

Background

Three well-reproduced findings in the fear conditioning literature are

  1. Spontaneous recovery: increasing time between extinction and test increases responding to the conditioned stimulus (CS).
  2. Reinstatement: after extinction, re-exposure to unconditioned stimulus (US) increases responding to the CS
  3. Renewal: after extinction, returning animal to acquisition context increases responding to the CS

Research Questions

Experiments

Exp 1 (Behavior)

1AB

Exp 2 (Behavior)

1AB

Exp 3 (Behavior)

1AB

Exp 4 (Neural)

Exp 5 (Behavior)

1AB

Exp 6 (Behavior)

1AB

tags: fear-conditioning