Rylan Schaeffer

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20 March 2021

Engram Cell Excitability State Determines the Efficacy of Memory Retrieval

by Pignatelli, ..., Tonegawa (Neuron 2019)

Research Questions

Excitability was previously shown to be key in determining which neurons are ultimately recruited to an engram (Yiu et al. 2014, Rashid et al. 2016). Here, the authors ask and answer:

Experiments

Exp 1 (Cellular)

Exp 2 (Behavioral)

3AB

Exp 3 (Behavioral)

3CDE

Exp 4 (Cellular, Neural, Behavioral)

4DE

tags: memory-engrams - dentate-gyrus - contextual-fear-conditioning