Rylan Schaeffer

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29 March 2021

Optogenetic stimulation of a hippocampal engram activates fear memory recall

by Liu and Ramirez, ..., Tonegawa (Nature 2012)

Background

Previously, ablating/inactivating memory engram neurons prevented retrieval of fear response

c-fos is an immediate early gene often used as marker of recent neuronal activity

Research Questions

Experiments

Exp 1 (Cellular)

Exp 2 (Neural, Behavioral)

3ABCDEF

Exp 3 (Neural)

Exp 4 (Neural, Behavioral)

tags: memory-engrams - contextual-fear-conditioning - dentate-gyrus - auditory-fear-conditioning