Rylan Schaeffer

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22 March 2021

The role of neuronal excitability, allocation to an engram and memory linking in the behavioral generation of a false memory in mice

by Lau, ..., Josselyn (Neurobiology of Learning and Memory 2020)

Background

Previously, Rashid et al. 2016 and Cai et al. 2016 showed that conditioning close in time result in overlapping engrams, and Yokose et al. 2017 further showed that the overlap in neurons between engrams is responsible for linking the shared experiences.

Research Questions

This paper asks and answers:

Experiments

Exp 1 (Behavior)

2A

2B

2C

2D

Exp 2 (Behavior)

3A

3B

Exp 3 (Neural)

4B

4BContro

Exp 4 (Neural)

5D

Exp 5 (Neural, Behavioral)

7_3h-RL

7_3h-RL

7_24h-RL

7_24h-RL

7B_part1

7B_part2

Exp 6 (Neural, Behavioral)

8A_part1

8A_part2

8C

tags: memory-engrams - lateral-amygdala - auditory-fear-conditioning - visual-fear-conditioning - optogenetics