Brain-wide Representations of Prior Information in Mouse Decision-making

Charles Findling, Felix Hubert, International Brain Laboratory, Luigi Acerbi, Brandon Benson, Julius Benson, Daniel Birman, Niccolo Bonacchi, E Kelly Buchanan, Sebastian Bruijns, Rylan Schaeffer

Nature Accepted

January 2025

Neuroscience Decision Making Neural Representations

Abstract

We investigate how prior information - expectations based on past experience - is represented and used across the brain during decision-making, revealing distributed encoding of expectations.

Summary

Brain-wide neural representations of prior information during mouse decision-making from the International Brain Laboratory.

The International Brain Laboratory

This work is part of the International Brain Laboratory (IBL) consortium effort to understand brain-wide neural computations during decision-making.

Key Contribution

We investigate how prior information - expectations based on past experience - is represented and used across the brain during decision-making. Our findings reveal that prior information is encoded in a distributed manner across many brain regions, coordinating to influence behavior.

My Role

Consortium author - contributed to data analysis and modeling. See paper for full author list.