Rylan Schaeffer

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Kernel Papers


21 March 2021

Overlapping memory trace indispensable for linking, but not recalling, individual memories

by Yokose, ..., Inokuchi (Science 2017)

Research Questions

Previous work (Rashid et al. 2016, Cai et al. 2016) showed that conditioning two unrelated conditioned stimuli (CSes) close in time would result in an overlapping memory engram (which I call an entangled engram).

“Memory traces for two independent emotional memories in the brain partially overlapped when the two memories were retrieved synchronously to create a linkage. Suppressing the activity of the overlapping memory trace interrupted the linkage without damaging the original memories.”

Experiments

Exp 1 (Behavior)

1A

1EF

Exp 2 (Behavioral & Neural)

1G

2A

2F

Exp 3 (Neural)

3J

3KL

3M

3O

Exp 4 (Neural)

Exp 5 (Neural)

4H

4IJK

tags: memory-engrams - amygdala - auditory-fear-conditioning - conditioned-taste-aversion - optogenetics