Rylan Schaeffer

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30 March 2021

Engram cells retain memory under retrograde amnesia

by Ryan, Roy, Pignattelli, ..., Tonegawa (Science 2015)

Background

Memory consolidation is process by which a new memory transitions from a fragile state to a long-term stable state. For short time after learning, memory is susceptible to disruption e.g. by protein synthesis inhibitor (PSI), which can cause retrograde amnesia.

Disclaimer: This paper explains its experiments very poorly. Reading the supplement directly is highly recommended.

Research Questions

Experiments

Exp 1 (Cellular)

Exp 2 (Behavioral)

Exp 3 (Behavioral)

Exp 4 (Behavioral)

Exp 5 (Behavioral)

Exp 6 (Behavioral)

Exp 7 (Neural)

tags: memory-engrams - dentate-gyrus - contextual-fear-conditioning - auditory-fear-conditioning - lateral-amygdala